Every alcohol-detoxing admission begins with a focused clinical assessment: quantity and frequency of daily alcohol use (grams of ethanol per day, drinking days per week), duration of heavy drinking, prior detox attempts, prior withdrawal seizures or DTs, cardiac and hepatic status, prescription and over-the-counter medications (especially other CNS depressants), and psychiatric history including suicidal ideation. Physical exam focuses on cardiovascular status, hepatic signs (jaundice, ascites, encephalopathy), neurological findings (tremor, ataxia, nystagmus suggesting Wernicke), and hydration.
Baseline laboratory includes CMP, CBC, hepatic panel, magnesium, phosphate, GGT, INR, urinalysis with urine drug screen, urine pregnancy in women of childbearing age, and a 12-lead EKG in patients over 50 or with cardiac risk. A CIWA-Ar score is obtained on admission and repeated every 4 hours across the first 72 hours (extended if withdrawal is prolonged). The first dose of benzodiazepine is triggered when the CIWA-Ar score is 8 or higher.
Chlordiazepoxide (Librium) is our default agent because its long half-life produces a gentler, self-tapering course; lorazepam (Ativan) is used instead in patients with significant hepatic impairment because it does not require hepatic oxidation. Typical dosing is 25-50 mg chlordiazepoxide (or 1-2 mg lorazepam) for CIWA scores 8-15, and 100 mg chlordiazepoxide (or 2-4 mg lorazepam) for scores 15 or higher, repeated as often as every hour early on. Peak daily requirement is usually reached by day 2, and dosing tapers naturally as symptoms subside.
IV thiamine 500 mg is administered daily for the first 3 days — before any glucose-containing IV fluid is hung — to prevent Wernicke encephalopathy, followed by oral thiamine 100 mg three times daily, oral folate, and a multivitamin. Magnesium sulfate 2-4 g IV corrects the hypomagnesemia that is nearly universal in chronic drinkers and reduces cardiac arrhythmia and seizure risk. Phosphate is repleted if serum phosphate drops below 2.0 mg/dL. Adjunctive gabapentin (300-600 mg TID) is added for craving and sleep in the last phase of detox; clonidine or propranolol may be used for persistent autonomic hyperactivity.